In the good old days, there was the phone interview and then the face to face interview. Now, for a lot of jobs, there’s an added middle step — the Skype interview. These are especially popular for jobs that aren’t just around the corner. Before a company is willing to pay to fly you out, they want to talk face to face, and this is the way to do it.
All the regular interview rule apply — speak slowly and clearly, focus on your accomplishments, don’t bad mouth your former employers, and wear proper interview clothing. Don’t be tempted to wear jeans and a t-shirt because it’s “just” a Skpe interview. (And even though it may be tempting to put on a button down shirt and tie on not bother with nice pants, you could get caught and wind up looking foolish, so dress properly from head to toe.)